Gleevec inhibits -amyloid production but not Notch cleavage
نویسندگان
چکیده
منابع مشابه
Gleevec inhibits -amyloid production but not Notch cleavage
Amyloid(A ) peptides, consisting mainly of 40 and 42 aa (A 40 and A 42, respectively), are metabolites of the amyloid precursor protein and are believed to be major pathological determinants of Alzheimer’s disease. The proteolytic cleavages that form the A N and C termini are catalyzed by -secretase and -secretase, respectively. Here we demonstrate that -secretase generation of A in an N2a cell...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1534745100